Scientists have developed a pioneering 3D-printed device that could speed up patient access to new medicines and eliminate the need for animal testing.
Thousands of animals are used in the early stages of developing medicines worldwide every year, yet many drugs tested on animals do not end up showing any clinical benefit.
Now researchers at the University of Edinburgh have designed a groundbreaking “body-on-chip” that perfectly mimics how a medicine flows through a patient’s body. The plastic device means scientists can test drugs to see how different organs react without the need for live animal testing.
The device invented in Edinburgh is the first of its kind in the world. Made using a 3D printer, the chip’s five compartments replicate the human heart, lungs, kidney, liver and brain. They are connected by channels that mimic the human circulatory system, through which new drugs can be pumped.
The plastic device uses positron emission tomography (PET) scanning to produce detailed 3D images showing what is going on inside the tiny organs. “The PET imagery is what allows us to ensure the flow [of new drugs being tested] is even,” said Liam Carr, the inventor of the device.
PET scanning involves injecting tiny amounts of radioactive compounds into the chip to transmit signals to an extremely sensitive camera, allowing scientists to better assess the effect of new drugs.
“This device is the first to be designed specifically for measuring drug distribution, with an even flow paired with organ compartments that are large enough to sample drug uptake for mathematical modelling. Essentially, allowing us to see where a new drug goes in the body and how long it stays there, without having to use a human or animal to test it.”
Carr added: “The platform is completely flexible and can be a valuable tool to investigate various human diseases, such as cancer, cardiovascular diseases, neurodegenerative diseases and immune diseases.
“Because of this flexibility, the uses are bound only by the availability of these cell models, and the scientific questions we can think of.
“For example, we could have a fatty liver disease model in the device and use this to see how having a diseased liver affects other organs such as the heart, brain, kidneys, etc, and could even combine multiple diseased cell models to see how diseases can interfere with each other.”
Carr’s supervisor, Dr Adriana Tavares, of Edinburgh’s Centre for Cardiovascular Science (CVS), said linking five organs together on one device would help scientists effectively study how a new drug might affect a patient’s whole body.
“This is a really important area of medical research, as we continuously learn about how diseases traditionally perceived to be restricted to an organ or system can have diverse effects across other distant organs or different interconnected systems.
“Devices such as the body-on-chip platform are essential to unravel the mechanisms underlying systemic effects of local diseases as well as investigate off-target effects of drugs, which might be therapeutically useful or detrimental.”
She added: “This device shows really strong potential to reduce the large number of animals that are used worldwide for testing drugs and other compounds, particularly in the early stages, where only 2% of compounds progress through the discovery pipeline.”
Tavares said there were other benefits beyond simply eliminating the need for using animals in early drug development.
“This non-animal approach could significantly reduce cost of drug discovery, accelerate translation of drugs into the clinic, and improve our understanding of systemic effects of human diseases, by using models that are more representative to human biology than animal models.”
The body-on-chip device was developed through a National Centre for Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and Unilever co-funded PhD studentship award.
Dr Susan Bodie, of Edinburgh Innovations, the university’s commercialisation unit, said: “We’re delighted to be supporting Liam and the CVS team in the development of this ‘body-on-chip’, and we look forward to seeing the impact this novel device has on the testing and progression of new compounds and drugs in the future.”
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